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Carotid arterial echography revealed significantly increased maximum intimamedia thickness (20.0220.079 mm) of carotid artery after treatment with alogliptin (25 mg/d for 24 months) indicated attenuated atherosclerosis [60]

Research suggests that paracetamol may act through additional mechanisms, including interactions with the endocannabinoid and serotonergic systems.^6^ This complexity challenges the traditional "one drug, one target" paradigm and demonstrates why tools like BioEmu, which can generate thousands of protein conformational states, are essential for understanding drug-target interactions

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